RESUMO
El objetivo fue describir el estado actual del marco normativo de migración, y la tendencia de indicadores de población y migración en Venezuela en el periodo 2000-2022.Métodos: Estudio descriptivo del marco normativo de migración y la tendencia de indicadores de población y migración en Venezuela. Indicadores: población total, tasa de dependencia demográfica (total, niñez, adulto mayor) y tasa de migración. Fuentes de datos: plataforma informativa salud y migración(marco normativo), Anuario estadístico de América Latina y el Caribe año 2000 al 2022 (indicadores de población).Resultados: El marco normativo de la migración en Venezuela está contenido en escasas leyes y Convenios Internacionales y regionales. La variación porcentual en la población venezolana fue descendente durante casi todo el periodo, donde se presentan incluso valores negativos para 2018-2021. La tasa anual decrecimiento poblacional, demostró un descenso constante y marcado desde el año 2000 hasta el año 2018, con altos valores negativos, luego asciende mostrando valores positivos a partir del año 2022, con un valor equivalente al año 2000. Conclusiones: El marco legal migratorio en Venezuela, es deficitario y no acorde a las necesidades de los migrantes. Los cambios ocurridos en la población venezolana de 2000 a 2022 fue debido a varios factores, siendo de gran impacto el fenómeno migratorio. La tasa de migración en Venezuela muestra tendencia negativa lo que indica que el país pierde población.
Objective Describe the current state of the regulatory framework for migration and the trend of populationand migration indicators in Venezuela for the period2000-2022. Methods: Descriptive study of the regulatory framework for migration and the trend of population andmigration indicators in Venezuela. Sample of national and international documents (regulatory framework). Indicators: total population, demographic dependency rate (total,childhood, elderly) and migration rate. Data sources: health andmigration information platform (regulatory framework) LatinAmerica and the Caribbean Statistical Yearbook 2000 to 2022(population indicators) Results: The regulatory framework formigration in Venezuela is contained in few international andregional laws and agreements. The percentage variation in the Venezuelan population was downward during almost the entireperiod, where even negative values are presented for 2018-2021.The annual rate of population growth showed a constant andmarked decrease from the year 2000 to the year 2018 with highnegative values, then it ascends showing positive values from theyear 2022 with a value equivalent to the year 2000. Conclusions:The migratory legal framework in Venezuela is deficient anddoes not meet the needs of migrants. The changes that haveoccurred in the Venezuelan population from 2000 to 2022 wasdue to several factors, the migratory phenomenon being of greatimpact. the migration rate in Venezuela shows a negative trend,which indicates that the country is losing population.
Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Emigração e Imigração/estatística & dados numéricos , Migração Humana/estatística & dados numéricos , Cooperação Internacional/legislação & jurisprudência , Fatores Socioeconômicos , Fatores de Risco , Estudos Populacionais em Saúde Pública , JurisprudênciaRESUMO
Background and purpose:The growth,metastasis,relapse and the prognosis of tumor are correlated with tumor angiogenesis.Therefore,target to angiogenesis and antiangiogenic therapy has become one of the hot points in cancer research field.Some chemotherapeutic drugs can inhibit the growth of new vascular endothelial cell markedly in the way of low-dose and high time administration.This is metronomic chemotherapy or antiangiogenic chemotherapy.Traditional Chinese medicine has an effect on tumor control.In recent years,we discovered that some traditional Chinese medicine have an antiangiogenic effect.This experiment aimed to study the antiangiogenetic ability of oxaliplatin combined with composite radix sophora flavescentis injection(CRSFI) in vitro and in vivo. Methods :We used MTT method to observe the influence of oxaliplatin and composite radix sophora flavescentis injection on human umbilical vein endothelial cells(HUVEC) or LoVo proliferation.The influence of oxaliplatin and composite radix sophora flavescentis injection on HUVEC migration was evaluated by transwell.Chick embryo chorioallantoic membrane(CAM)model was used to check whether the neovascularization of CAM could be suppressed in vivo by them. Results :The survival rate of LoVo within the same doses of oxaliplatin and composite radix sophora flavescentis injection were higher than HUVEC.Oxaliplatin(2 ?g/ml) and composite radix sophora flavescentis Injection(25 ?l/ml) could inhibit the prolifetation of HUVEC;the rate of inhibition were 31.6%,32.1% respectively;the rate of the two drugs combination was 54.4%.So when combined,they had synergistic effect.There was coordinate repression to migration of HUVEC in vitro when we used oxaliplatin(0.5 ?g/ml) and composite radix sophora flavescentis injection(6.25 ?l/ml).They also suppressed angiogenesis of CAM in vivo. Conclusions :This experiment showed that low dose oxaliplatin combined with composite radix sophora flavescentis injection has anti-angiogenic synergetic ability in vivo and the ability of inhibiting the growth of the cells in vitro.